Invitrogen™ Human RGS22 Synthetic Peptide

Catalog No.	Quantity
PEP1468	50 μg

Catalog No. PEP1468 Supplier Invitrogen™ Supplier No. PEP1468

Description

Synthetic Peptide

This peptide corresponds to 19 amino acid peptide near the amino terminus of human RGS22. PEP-1468 can be used as a blocking peptide with polyclonal antibody PA5-34426.

Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS22 is a recently identified member of this family that localizes to the testis and can interact with guanine nucleotide binding proteins alpha 11, 12, and 13 (GNA11, GNA12, and GNA13). While RGS22 has been postulated to play a role in spermiogenesis in the testis, it is also expressed in several cancer cell lines with an epithelial origin and associated with cancer metastasis. Its overexpression in a highly metastatic cancer causes a decrease in cell migration and a reduction of the invasive potential of the cells, suggesting that RGS22 may be a potential prognostic biomarker for metastasis.

Specifications

• Gene ID (Entrez): 26166
• Species: Human
• Purification Method: purified
• Accession Number: Q8NE09
• Common Name: RGS22
• Concentration: 200 μg/mL
• Content And Storage: -20°C
• Description: Synthetic Peptide
• Format: Liquid
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
• For Use With (Application): Blocking Assay, Control
• Gene Alias: CT145; PRTD-NY2; Regulator of G-protein signaling 22; regulator of G-protein signalling 22; RGD1565493; Rgs22
• Gene Symbol: RGS22
• Lyophilized: No
• Preservative: Sodium azide
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO
• Storage Buffer: PBS