Invitrogen™ Human RHBDD1 Synthetic Peptide

Catalog No.	Quantity
PEP0974	50 μg

Catalog No. PEP0974 Supplier Invitrogen™ Supplier No. PEP0974

Description

Synthetic Peptide

This peptide corresponds to 14 amino acids near the carboxy terminus of human RHBDD1. PEP-0974 can be used as a blocking peptide with polyclonal antibody PA5-20860.

The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity. In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.

Specifications

• Gene ID (Entrez): 84236
• Species: Human
• Purification Method: purified
• Accession Number: Q8TEB9
• Common Name: RHBDD1
• Concentration: 200 μg/mL
• Content And Storage: -20°C
• Description: Synthetic Peptide
• Format: Liquid
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
• For Use With (Application): Blocking Assay, Control
• Gene Alias: 4930418P06Rik; HSD50; HSD-50; mRHBDD1; MSD50; MSD-50; RGD1306477; RHBDD1; Rhbdl4; rhomboid domain containing 1; rhomboid domain-containing protein 1; Rhomboid-like protein 4; rhomboid-related protein 4; rRHBDD1; RRP4
• Gene Symbol: RHBDD1
• Lyophilized: No
• Preservative: Sodium azide
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO
• Storage Buffer: PBS