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Invitrogen™ eBioscience™ Human sCD28 Platinum ELISA Kit Non-distribution product as customer accommodation.

For the quantitative detection of human sCD28.

Manufacturer:  Invitrogen™ BMS290

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Catalog No. 50-182-42


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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human sCD28
Biotin-Conjugate anti-human sCD28 monoclonal antibody
Streptavidin-HRP
Human sCD28 Standard lyophilized, 100ng/mL upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.
Specifications

Specifications

P10747
Biotin
940
Adhesive Plate Covers
96 tests
0.18 ng/mL
50μL
Human
1 hr 20 min
Human
T-cell-specific surface glycoprotein, TP 44
5.9%
0.78-50 ng/mL
ELISA
Colorimetric Microplate Reader
ELISA
RUO
Serum, Supernatants
Serum (50μL), Supernatants (50μL)
2-8°C
3 hr 10 min
CD28
7.2%
HRP
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