Invitrogen™ Human SDPR (aa 263-396) Control Fragment Recombinant Protein

Catalog No.	Quantity
RP90829	100 μL

Catalog No. RP90829 Supplier Invitrogen™ Supplier No. RP90829

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (72%), Rat (72%). This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.

Specifications

• Accession Number: O95810
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Neutralization, Control
• Formulation: PBS, 1M urea with no preservative; pH 7.4
• Gene ID (Entrez): 8436
• Name: Human SDPR (aa 263-396) Control Fragment
• pH Range: 7.4
• Purification Method: Purified
• Quantity: 100 μL
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: caveolae associated protein 2; caveolae-associated protein 2; cavin 2; CAVIN2; cavin-2; EMBL:AAH81956.1}; phosphatidylserine binding protein; phosphatidylserine-binding protein; PS-p68; SDPR; sdpr {ECO:0000312; SDR; serum deprivation response; serum deprivation response protein; serum deprivation-response protein
• Common Name: SDPR
• Gene Symbol: CAVIN2
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: VSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYE
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining