Invitrogen™ ICAM-1 (Soluble) Human ELISA Kit
For the quantitative detection of human sICAM-1.
Manufacturer: Invitrogen™ BMS201TEN
DescriptionICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
|Pre-coated 96 well plates, Standard, Sample Diluent, Assay Buffer concentrate, Detection Antibody Conjugate: anti-rabbit-HRP, Wash Buffer, Chromogen, Stop Solution, Controls, Adhesive Plate Covers|
|Plasma, 10 μL; Serum, 10 μL; Supernatant, 10 μL|
|1 hr. 20 min.|
|10 x 96 Tests|
|Plasma, Serum, Supernatant|
|Colorimetric Microplate Reader|
|2°C to 8°C|
|1 hr. 10 min.|
|Intercellular adhesion molecule 1, CD54 antigen|
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For Research Use Only