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  5. Invitrogen™ Human SIGIRR ELISA Kit 

Invitrogen™ Human SIGIRR ELISA Kit

Catalog No. EH422RBX5
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Description

ELISA

Human SIGIRR quantitates human SIGIRR in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human SIGIRR.

SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data that suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number AI256711; IL-1R8; MGC110992; Sigirr; single Ig and TIR domain containing; single Ig IL-1 receptor related protein; Single Ig IL-1-related receptor; single Ig IL-1 R-related molecule; single Ig IL-1 R-related protein; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single immunoglobulin domain IL1R1 related; single immunoglobulin domain-containing IL1R-related protein; Tir8; Toll/interleukin-1 receptor 8; UNQ301/PRO342
Assay Range 2 to 500 ng/mL
Assay Sensitivity 2 ng/mL
Conjugate HRP
Product Type ELISA
Sample Type Plasma, Serum, Supernatant
For Use With (Equipment) Colorimetric Microplate Reader
Gene ID (Entrez) 59307
Gene Symbol SIGIRR
Interassay CV <12%
Intraassay CV <10
Kit Contents Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
Label or Dye HRP
Quantity 5 x 96 Tests
Regulatory Status RUO
Sample Volume Plasma 50 μL, Serum 50 μL, Supernatant 50 μL
Storage Requirements 2°C to 8°C
Target SIGIRR
Test Time 1 hrs 20 mins
Total Assay Time 4 hrs 45 mins
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