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Invitrogen™ Human Stem Cell Factor (SCF) Synthetic Peptide
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Quantity:
50 μg
Description
SCF Synthetic Peptide, PEP-0860, from Invitrogen.
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.

Specifications
Specifications
Gene ID (Entrez) | 4254 |
Species | Human |
Purification Method | purified |
Accession Number | P21583 |
Common Name | Human Stem Cell Factor (SCF) |
Concentration | 200 μg/mL |
Content And Storage | -20°C |
Description | Synthetic Peptide |
Format | Liquid |
Formulation | PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2 |
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