Gibco™ Human TGFBR1 (soluble) Fc Recombinant Protein, PeproTech®

Catalog No.	Quantity
50-003-31924	100 μg
50-003-31925	10 μg
50-003-31928	1 mg
50-003-31926	250 μg
50-003-31927	500 μg
50-003-31918	50 μg

Catalog No. 50-003-31924 Supplier Gibco™ Supplier No. 10021R1100UG

Description

Recombinant Protein

Recombinant Human sTGF-beta Receptor I Fc is a 72.4 kDa glycosylated, disulfide-linked homodimer whose 326 amino-acid monomer consists of the 126-amino-acid portion of the extracellular domain fused to the 231-amino-acid length Fc portion of Human IgG by two glycine residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis.

TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

Specifications

• Accession Number: P36897
• For Use With (Application): Binding Assay, Bioactivity
• Formulation: Protein with no preservative
• Gene ID (Entrez): 7046
• Molecular Weight (g/mol): 36.2 kDa
• Name: Human TGFBR1 (soluble) Fc
• Purification Method: Purified
• Quantity: 100 μg
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: AAT5; activin A receptor type II-like kinase, 53kDa; activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ACVRLK4; ALK5; Alk-5; AU017191; ESK2; ESS1; LDS1; LDS1A; LDS2A; MSSE; mutant transforming growth factor beta receptor I; ser; serine/threonine-protein kinase receptor R4; SKR4; TbetaRI; tbetaR-I; tgf beta receptor 1; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFBR1; TGFR1; TGFR-1; Transfor; transforming growth factor beta receptor 1; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa); transforming growth factor-beta receptor type I
• Common Name: TGFBR1
• Gene Symbol: TGFBR1
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Protein Tag: Fc-tag
• Sequence: LQCFCHLCTK DNFTCVTDGL CFVSVTETTD KVIHNSMCIA EIDLIPRDRP FVCAPSSKTG SVTTTYCCNQ DHCNKIELPT TVKSSPGLGP VELGGPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
• Activity: Determined by its ability to bind Human TGF-ß RII Fc in the presence of Human TGF-ß1 in a Functional ELISA.
• Expression System: CHO cells
• Form: Lyophilized
• Purity or Quality Grade: ≥ 95% by SDS-PAGE gel and HPLC analyses.