Invitrogen™ Human TMEFF1 (aa 53-72) Control Fragment Recombinant Protein

Catalog No.	Quantity
RP101483	100 μL

Catalog No. RP101483 Supplier Invitrogen™ Supplier No. RP101483

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (85%), Rat (85%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-62420. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

The TMEFF1 gene encodes the protein transmembrane protein with ependymin domain 1, which is involved in cellular signaling and neural development. TMEFF1, characterized by its transmembrane and ependymin-related domains, plays a role in the modulation of cell-cell interactions and signaling pathways essential for brain development and function. This protein is expressed predominantly in the central nervous system, where it influences neuronal differentiation and synaptic formation, contributing to the establishment and maintenance of neural circuits. TMEFF1 has been implicated in neuroprotective functions, where it supports neuronal survival in response to stress or injury. Additionally, its expression has been studied in the context of cancer biology, particularly in brain tumors, where TMEFF1 might impact tumor growth and progression through its effects on cell signaling and adhesion. Research continues to explore the specific mechanisms and interactions of TMEFF1 to better understand its roles in neural health and disease, particularly in neurodevelopmental disorders and cancer.

Specifications

• Accession Number: Q8IYR6
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Neutralization, Control
• Formulation: PBS, 1M urea with no preservative; pH 7.4
• Gene ID (Entrez): 8577
• Name: Human TMEFF1 (aa 53-72) Control Fragment
• pH Range: 7.4
• Purification Method: Purified
• Quantity: 100 μL
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: A830033E11; C9orf2; cancer/testis antigen family 120, member 1; CT120.1; H7365; H7365member 1; M7365; Nc1; Protein NC1; TMEFF1; Tomoregulin-1; Tr1; TR-1; transmembrane protein with EGF like and two follistatin like domains 1; transmembrane protein with EGF-like and one follistatin-like domain; transmembrane protein with EGF-like and two follistatin-like domains 1
• Common Name: TMEFF1
• Gene Symbol: TMEFF1
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: DCPGGKGKSINCSELNVRES
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining