Invitrogen™ Human TNIP3 Synthetic Peptide

Catalog No.	Quantity
PEP0912	50 μg

Catalog No. PEP0912 Supplier Invitrogen™ Supplier No. PEP0912

Description

Synthetic Peptide

This peptide corresponds to 17 amino acids near the carboxy terminus of human ABIN3. PEP-0912 can be used as a blocking peptide with polyclonal antibody PA5-20798.

The nuclear factor NF-kappa-B plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kappa-B activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kappa-B activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kappa-B activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kappa-B inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kappa-B in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.

Specifications

• Gene ID (Entrez): 79931
• Species: Human
• Purification Method: purified
• Accession Number: Q96KP6
• Common Name: TNIP3
• Concentration: 200 μg/mL
• Content And Storage: -20°C
• Description: Synthetic Peptide
• Format: Liquid
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
• For Use With (Application): Blocking Assay, Control
• Gene Alias: 9030611K07Rik; A20-binding inhibitor of NF-kappa-B activation 3; ABIN3; ABIN-3; ABIN-3 beta; LIND; Listeria induced; listeria-induced gene protein; TNFAIP3 interacting protein 3; TNFAIP3-interacting protein 3; TNFAIP3-interacting protein 3 beta; Tnip3; TNIP3 beta
• Gene Symbol: TNIP3
• Lyophilized: No
• Preservative: Sodium azide
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO
• Storage Buffer: PBS