Invitrogen™ Human TRPC6 Synthetic Peptide

Catalog No.	Quantity
PEP0393	50 μg

Catalog No. PEP0393 Supplier Invitrogen™ Supplier No. PEP0393

Description

Synthetic Peptide

This peptide corresponds to 14 amino acids near the amino terminus of human TRPC6. PEP-0393 can be used as a blocking peptide with polyclonal antibody PA5-20257.

Trpc6 forms a receptor-activated calcium channel in the cell membrane. The Trpc6 channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of the Trpc6 channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in the Trpc6 gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). Further, Trpc6 is a member of the mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the 'canonical TRP' (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, Trpc6 acts as a non-selective store-independent receptor-activated cation channel. Trpc6 is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that Trpc6 encodes endogenous DAG-activated receptor-operated cation channels in vivo. Diseases associated with TRPC6 include Glomerulosclerosis, Focal Segmental, 2 and Focal Segmental Glomerulosclerosis.

Specifications

• Gene ID (Entrez): 7225
• Species: Human
• Purification Method: purified
• Accession Number: Q9Y210
• Common Name: TRPC6
• Concentration: 200 μg/mL
• Content And Storage: -20°C
• Description: Synthetic Peptide
• Format: Liquid
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
• For Use With (Application): Blocking Assay, Control
• Gene Alias: AV025995; bZ1P14.9; calcium entry channel; FLJ11098; FLJ14863; focal segmental glomerulosclerosis 2; FSGS2; HGNC:12338; LLHWJM002; LLHWJM003; LLHWJM004; mtrp6; Short transient receptor potential channel 6; short transient receptor potential channel 6; short transient receptor potential channel 6a; si:rp71-1p14.9; transient receptor potential cation channel subfamily C member 6; transient receptor potential cation channel subfamily c member 6a; transient receptor potential cation channel TRPC6; transient receptor potential cation channel, subfamily C, member 6; transient receptor potential cation channel, subfamily C, member 6a; transient receptor potential channel 6; transient receptor potential channel subfamily C member 6; transient receptor protein 6; TRP6; TRP-6; trp6A; TRPC6; trpc6a; Trrp6
• Gene Symbol: Trpc6
• Lyophilized: No
• Preservative: Sodium azide
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO
• Storage Buffer: PBS