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Enzo Life Sciences Humanin (human) (0.5mg). CAS: 330936-69-1
Supplier: Enzo Life Sciences ALX158011MC05
Bax inhibitor. Humanin was originally identified as an anti-apoptotic peptide of 24 aa encoded in a cDNA that rescued neuronal cells from apoptosis induced by presenilin mutants associated with familial Alzheimer's disease and by amyloid-β protein. Mutagenesis studies showed that the cysteine at position 8 of the humanin peptide is critical for its anti-apoptotic function. It has now been shown that Bax (Bcl-2 associated X protein), an apoptosis-inducing protein, interacts with humanin. Humanin prevents the translocation of Bax from the cytosol to mitochondria. Humanin peptides also block Bax association with isolated mitochondria, and suppress cytochrome c release in vitro. Formula: C119H204N34O32S2. MW: 2687.3. Purity: ≥98% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in DMSO or 5% acetic acid. Long Term Storage: -20°C.
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