Sigma Aldrich Hydroxy-Peg4-T-Butyl Ester

Catalog No.	Quantity
90-258-61G	100 mg

Catalog No. 90-258-61G Supplier Sigma Aldrich Supplier No. 9025861G

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC™ molecules) for targeted protein degradation.Recruiting cytotoxic T cells to folate-receptor-positive cancer cellsSyntheses and characterizations of novel pyrrolocoumarin probes for SNAP-tag labeling technologyHigh density orthogonal surface immobilization via photoactivated copper-free click chemistryPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

• CAS: 14216-22-9
• Molecular Formula: C11H21ClN4O4
• Linear Formula: C11H21ClN4O4
• Quantity: 100 mg
• Synonym: tert-Butyl-1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate; HO-PEG4-CO-OtBu
• Molecular Weight (g/mol): 308.76 g/mol