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Medchemexpress LLC Α-hydroxyglutaric acid disodium | 40951-21-1 | 98.0% | 192.08 | 10 MG
SDP

Catalog No. 5000440046
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α-Hydroxyglutaric acid disodium is an α-hydroxy acid form of glutaric acid. It acts as a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methylcytosine (5mC) hydroxylases. This compound is involved in biological activities related to IDH1 and IDH2 mutations, often found in gliomas and acute myeloid leukemia.

  • An alpha-hydroxy acid form of glutaric acid
  • Competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
  • Inhibits histone demethylases and TET 5-methylcytosine hydroxylases
  • Increases HIF-1 alpha and decreases endostatin in U-87MG cells
  • Plays a role in IDH1 and IDH2 mutations related to gliomas and acute myeloid leukemia

Catalog No. 50-004-40046 Supplier Medchemexpress LLC Supplier No. HY113038A10MG
May include imposed supplier surcharges.
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α-Hydroxyglutaric acid disodium is an α-hydroxy acid form of glutaric acid. It acts as a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methylcytosine (5mC) hydroxylases. This compound is involved in biological activities related to IDH1 and IDH2 mutations, often found in gliomas and acute myeloid leukemia.

  • An alpha-hydroxy acid form of glutaric acid
  • Competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
  • Inhibits histone demethylases and TET 5-methylcytosine hydroxylases
  • Increases HIF-1 alpha and decreases endostatin in U-87MG cells
  • Plays a role in IDH1 and IDH2 mutations related to gliomas and acute myeloid leukemia

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