Apexbio Technology LLC Hydroxyurea 127-07-1 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B21025.1

Hydroxyurea is a potent inhibitor of ribonucleoside diphosphate reductase a rate-limiting enzyme converting ribonucleotides to deoxyribonucleotides thereby interrupting DNA synthesis and arresting cells in the S-phase of the cell cycle Its reported IC50 values approximate 1 5 mM Hydroxyurea has demonstrated potential in biomedical research settings including inhibition of HIV-1 replication in activated peripheral blood mononuclear cells (PBMCs) with an IC90 of around 0 4 mM induction of fetal hemoglobin (HbF) in erythroid cells from -thalassemia/hemoglobin E patients and tumor growth suppression in various tumor xenograft animal models when used in combination therapy regimens

Catalog No. 50-000-62292