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Cayman Chemical HydroxyzIn 100mg
Supplier: Cayman Chemical 24039100 MG
A histamine H1 receptor antagonist (Ki = 1.9 nM); binds competitively with the H1 receptor inverse agonist mepyramine in polymorphonuclear leukocytes (IC50 = 80 µM); metabolized to cetirizine in vivo; prevents histamine-induced recruitment of rolling leukocytes in rat mesentery post-capillary venules in situ (10 µM); decreases anxiety-like behavior in mice in the elevated plus maze and light-dark exploration test
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