Hygromycin B, Thermo Scientific Chemicals PROMO

Description

Hygromycin B, CAS # 31282-04-9, is an aminoglycoside compound showing antibiotic activity that kills bacteria through the inhibition of protein synthesis. It also presents anthelmintic activity.

General Description

• Hygromycin is an aminoglycosidic compound that shows antibiotic activity. It is produced by Streptomyces hygroscopicus
• Hygromycin acts against both prokaryotic and eukaryotic cells, having the ability to inhibit protein synthesis. It also stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. This compound prevents ribosome translocation during translation elongation by binding the 30S rRNA proximal to the ribosomal E, P, and A sites

Application

• In clinical and plant research, this compound can be used as a marker to select and maintain prokaryotic and eukaryotic cells containing the hygromycin resistance gene
• Hygromycin also presents an anthelmintic activity against nematode parasites of chickens

Specifications

Chemical Identifiers

• CAS: 31282-04-9
• Molecular Formula: C20H37N3O13
• Molecular Weight (g/mol): 527.524 g/mol
• MDL Number: MFCD06795479
• InChI Key: GRRNUXAQVGOGFE-BBMONYMYSA-N
• PubChem CID: 134129613
• IUPAC Name: (3'S,3aS,4S,4'S,5'R,6R,6'R,7R,7aS)-4-[(1R,2S,3R,5S,6S)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
• SMILES: CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N

• Type: Hygromycin B
• Physical Form: Lyophilized Powder
• Color: Brown
• Quantity: 250 mg
• UN Number: UN3462
• Merck Index: 14,4852
• Solubility Information: Miscible with Water,methanol,buffer solution and ethanol; Immiscible with less polar solvents.
• Formula Weight: 527.53 g/mol
• Chemical Name or Material: Hygromycin B

Safety and Handling

Hazard Category	H300+H310+H330-H317-H318-H334
Hazard Statement	GHS H Statement: H300-H310-H330-H334-H318-H317. Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes serious eye damage. May cause an allergic skin reaction.
Precautionary Statement	P260-P262-P264b-P270-P271-P272-P280-P284-P285-P301+P310-P302+P350-P304+P340-P305+P351+P338-P310-P330-P333+P313-P361-P363-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: I; Proper Shipping Name: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S.
EINECSNumber	250-545-5
RTECSNumber	WK2130000
TSCA	No
Recommended Storage	Keep Cold

RUO – Research Use Only