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Hygromycin B, Thermo Scientific Chemicals PROMO

Catalog No. J60681MDPM
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Catalog No.
J60681MDPM 250 mg
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Catalog No. J60681MDPM Supplier Thermo Scientific Chemicals Supplier No. J60681MDPR

Description

Hygromycin B, CAS # 31282-04-9, is an aminoglycoside compound showing antibiotic activity that kills bacteria through the inhibition of protein synthesis. It also presents anthelmintic activity.

General Description

  • Hygromycin is an aminoglycosidic compound that shows antibiotic activity. It is produced by Streptomyces hygroscopicus
  • Hygromycin acts against both prokaryotic and eukaryotic cells, having the ability to inhibit protein synthesis. It also stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. This compound prevents ribosome translocation during translation elongation by binding the 30S rRNA proximal to the ribosomal E, P, and A sites

Application

  • In clinical and plant research, this compound can be used as a marker to select and maintain prokaryotic and eukaryotic cells containing the hygromycin resistance gene
  • Hygromycin also presents an anthelmintic activity against nematode parasites of chickens
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 31282-04-9
Molecular Formula C20H37N3O13
Molecular Weight (g/mol) 527.524 g/mol
MDL Number MFCD06795479
InChI Key GRRNUXAQVGOGFE-BBMONYMYSA-N
PubChem CID 134129613
IUPAC Name (3'S,3aS,4S,4'S,5'R,6R,6'R,7R,7aS)-4-[(1R,2S,3R,5S,6S)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
SMILES CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N

Specifications

Type Hygromycin B
Physical Form Lyophilized Powder
Color Brown
Quantity 250 mg
UN Number UN3462
Merck Index 14,4852
Solubility Information Miscible with Water,methanol,buffer solution and ethanol; Immiscible with less polar solvents.
Formula Weight 527.53 g/mol
Chemical Name or Material Hygromycin B

Safety and Handling

Hazard Category H300+H310+H330-H317-H318-H334
Hazard Statement GHS H Statement: H300-H310-H330-H334-H318-H317. Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes serious eye damage. May cause an allergic skin reaction.
Precautionary Statement P260-P262-P264b-P270-P271-P272-P280-P284-P285-P301+P310-P302+P350-P304+P340-P305+P351+P338-P310-P330-P333+P313-P361-P363-P501c
DOTInformation Transport Hazard Class: 6.1; Packing Group: I; Proper Shipping Name: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S.
EINECSNumber 250-545-5
RTECSNumber WK2130000
TSCA No
Recommended Storage Keep Cold

RUO – Research Use Only

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