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Vector Biolabs Hypoxia-inducible factor 1, alpha subunit inhibitor Adenovirus (Ad-HIF1AN/FIH1)

Supplier:  Vector Biolabs 1551

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Factor inhibiting HIF-1 (FIH-1) exists as a homodimer and binds to HIF-1-alpha. Specifically, FIH-1 operates as an asparaginyl hydroxylase and catalyzes the hydroxylation of the beta-carbon of asparagine residue 803 within the C-terminal transactivation domain of HIF-1-alpha. This hyroxylation event blocks the association of HIF-1alpha with coactivators.

Catalog No. 50-004-96582


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