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Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 100 MG
SDP

Supplier:  Medchemexpress LLC HY153365100MG

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I-138 is an orally active, reversible inhibitor of USP1-UAF1. It induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage. This compound is structurally related to ML323.

  • Orally active and reversible inhibitor of USP1-UAF1
  • Induces monoubiquitination of FANCD2 and PCNA in cells
  • Eliminates USP1 autocleavage in cells
  • Shows dose-dependent inhibition of MDA-MB-436 cell viability
  • Exhibits modest antitumor activity in mice bearing MDA-MB-436 tumors
  • Can be combined with Niraparib for BRCA1/2 mutant tumor inhibition in vivo

Catalog No. 50-003-72819


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