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Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 50 MG
SDP

Catalog No. 5000373523
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I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323. It induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells.

  • Eliminates USP1 self-lysis in HAP-1 USP1 WT and knockout cells
  • Induces monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells
  • Dose-dependently inhibits MDA-MB-436 cell viability
  • Results in USP1 inhibition and modest antitumor activity in mice bearing MDA-MB-436 tumors
  • Benefits BRCA1/2 mutant tumor inhibition when combined with Niraparib

Catalog No. 50-003-73523 Supplier Medchemexpress LLC Supplier No. HY15336550MG
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I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323. It induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells.

  • Eliminates USP1 self-lysis in HAP-1 USP1 WT and knockout cells
  • Induces monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells
  • Dose-dependently inhibits MDA-MB-436 cell viability
  • Results in USP1 inhibition and modest antitumor activity in mice bearing MDA-MB-436 tumors
  • Benefits BRCA1/2 mutant tumor inhibition when combined with Niraparib

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