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Medchemexpress LLC I-287 | 2014368-93-3 | 99.4% | 565.04 | 1 ML
SDP

Catalog No. 5000360524
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I-287 is an orally active, selective PAR2 inhibitor that acts as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. It has been shown to reduce Complete Freund's adjuvant-induced inflammation in mice and can be used for inflammation/immunology research.

  • Inhibits PAR2-mediated activation of Gαq and Gα12/13
  • Inhibits PAR2-mediated ERK1/2 activation in HEK293 cells
  • Inhibits PAR2-induced secretion of IL-8 cytokine in HCT-116 and A549 cells
  • Reduces Complete Freund's adjuvant-induced inflammation in C57BL/6J mice

Catalog No. 50-003-60524 Supplier Medchemexpress LLC Supplier No. HY14801610MM/1ML
May include imposed supplier surcharges.
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I-287 is an orally active, selective PAR2 inhibitor that acts as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. It has been shown to reduce Complete Freund's adjuvant-induced inflammation in mice and can be used for inflammation/immunology research.

  • Inhibits PAR2-mediated activation of Gαq and Gα12/13
  • Inhibits PAR2-mediated ERK1/2 activation in HEK293 cells
  • Inhibits PAR2-induced secretion of IL-8 cytokine in HCT-116 and A549 cells
  • Reduces Complete Freund's adjuvant-induced inflammation in C57BL/6J mice

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