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Medchemexpress LLC I-287 | 2014368-93-3 | 99.4% | 565.04 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY148016

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I-287 is an orally active, selective PAR2 inhibitor. It acts as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. It reduces Complete Freund's adjuvant (HY-153808)-induced inflammation in mice and can be used for inflammation/immunology research.

  • Reduces Complete Freund's adjuvant-induced inflammation in mice.
  • Can be used for inflammation/immunology research.
  • Inhibits PAR2-mediated activation of Gαq and Gα12/13.
  • Does not affect Gi/o proteins.
  • No impact on PAR2-mediated recruitment of βarrestin2 and receptor internalization.
  • Inhibits PAR2-mediated ERK1/2 activation in HEK293 cells.
  • Inhibits PAR2-induced secretion of IL-8 cytokine in HCT-116 and A549 cells.

Catalog No. 50-003-63473


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