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Medchemexpress LLC I-287 | 2014368-93-3 | 99.4% | 565.04 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1480165MG

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I-287 is an orally active, selective PAR2 inhibitor that acts as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. It has been shown to reduce Complete Freund's adjuvant (CFA)-induced inflammation in mice and can be utilized for inflammation/immunology research.

  • Inhibits PAR2-mediated activation of Gαq and Gα12/13.
  • No effect on PAR2-mediated recruitment of βarrestin2 or receptor internalization.
  • Inhibits PAR2-mediated ERK1/2 activation in HEK293 cells.
  • Inhibits PAR2-induced secretion of IL-8 cytokine in HCT-116 and A549 cells.
  • Reduces CFA-induced inflammation in C57BL/6J mice.

Catalog No. 50-003-61340


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