Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000361339

Medchemexpress LLC I-287 | 2014368-93-3 | 99.4% | 565.04 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY14801650MG

Encompass_Preferred

I-287 is an orally active, selective PAR2 inhibitor that functions as a negative allosteric regulator of Gαq and Gα12/13 activity and their downstream effectors. It has been shown to reduce Complete Freund's adjuvant (CFA)-induced inflammation in mice and is suitable for inflammation/immunology research.

  • Selectively targets Gαq and Gα12/13 signaling
  • Inhibits PAR2-mediated activation of proteins without impacting βarrestin2 recruitment or receptor internalization
  • Inhibits PAR2-mediated ERK1/2 activation in HEK293 cells
  • Inhibits PAR2-induced secretion of IL-8 cytokine in HCT-116 and A549 cells
  • Reduces inflammation in C57BL/6J mice

Catalog No. 50-003-61339


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.