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Apexbio Technology LLC I-CBP 112 1640282-31-0 10mg
Supplier: Apexbio Technology LLC A449010
I-CBP 112 (CAS 1640282-31-0) is a selective small-molecule inhibitor targeting the bromodomains of CREBBP (CBP) and EP300 two epigenetic regulators involved in transcriptional control In biochemical assays I-CBP 112 demonstrates an IC50 of 170 nM against CREBBP with marked selectivity over other bromodomain-containing proteins such as ATAD2 BAZ2B and members of the BET family In vitro studies indicate that I-CBP 112 does not exhibit significant cytotoxicity in U2OS cells at concentrations up to 50 M Currently this compound is utilized predominantly in cellular and molecular studies to dissect the function of CREBBP/EP300 bromodomains in gene regulation with ongoing use limited to preclinical in vitro research contexts
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