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Cayman Chemical I-CBP112hydrochlorIde 10mg
Supplier: Cayman Chemical 1446810 MG
A p300 and CBP inhibitor; binds to the p300 and CBP bromodomains (Kds = 167 and 151 nM, respectively); selective for p300 and CBP over BRD4, as well as a panel of 104 nuclear receptors and ion channels and a panel of 32 enzymes at 10 µM; displaces acetylated histones from CBP in a cell-free assay (IC50 = 170 nM); reduces colony formation and increases differentiation of primary murine leukemic blasts and delays disease initiation following leukemic blast transplantation into sub-lethally irradiated mice when used at concentrations of 5 and 10 µM
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