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Medchemexpress LLC IACS-010759 hydrochloride | 1807523-99-4 | 99.6% | 599.02 | 1 ML
Supplier: Medchemexpress LLC HY112037A10MM/1ML
This orally active, potent mitochondrial complex I inhibitor of oxidative phosphorylation (OXPHOS) reduces cell viability and induces apoptosis in primary acute myeloid leukemia (AML) models. It is similarly active in mouse, rat, and cynomolgus monkey cell lines, demonstrating potential for relapsed/refractory AML and solid tumor research.
- Inhibits mitochondrial complex I of oxidative phosphorylation.
- Inhibits proliferation and induces apoptosis in models reliant on OXPHOS.
- Active across various mammalian cell lines.
- Has potential for addressing relapsed/refractory AML and solid tumors.
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