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Medchemexpress LLC IACS-13909 | 2160546-07-4 | 100.0% | 377.27 | 1 ML
Supplier: Medchemexpress LLC HY13709210MM/1ML
IACS-13909 is a selective, potent, and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. It demonstrates greater selectivity for SHP2 compared to other phosphatases, including SHP1. This inhibitor exhibits antitumor activities and inhibits MAPK pathway signaling in receptor tyrosine kinase (RTK)-dependent cancers.
- Selective, potent, and orally active SHP2 allosteric inhibitor
- IC50 of 15.7 nM and Kd of 32 nM for SHP2
- Greater selectivity for SHP2 compared to other phosphatases
- Exhibits antitumor activities
- Inhibits MAPK pathway signaling in RTK-dependent cancers
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