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Medchemexpress LLC Iacs-13909 | 2160546-07-4 | 99.9% | 377.27 | 100 MG
Supplier: Medchemexpress LLC HY137092100MG
IACS-13909 is a selective, potent, and orally active allosteric SHP2 inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. It demonstrates greater selectivity for SHP2 over other phosphatases, including SHP1. It exhibits antitumor activities and can suppress MAPK pathway signaling in receptor tyrosine kinase (RTK)-dependent cancers.
- Potently suppresses proliferation of wild-type SHP2 and KYSE-520 cells.
- Suppresses pERK and pMEK levels in wild-type SHP2 and KYSE-520 cells.
- Suppresses proliferation of both parental and NCI-H1975 CS cells in a dose-dependent manner.
- Potently suppresses tumor growth in NSG mice injected with KYSE-520 cells, achieving 100% tumor growth inhibition.
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