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Medchemexpress LLC IACS-13909 | 2160546-07-4 | 99.97% | 377.27 | 50 MG
Supplier: Medchemexpress LLC HY13709250MG
IACS-13909 is a selective, potent, and orally active allosteric inhibitor of SHP2. It demonstrates an IC50 of 15.7 nM and a Kd of 32 nM, exhibiting higher selectivity for SHP2 compared to other phosphatases, including SHP1. This compound possesses antitumor activities and effectively suppresses MAPK pathway signaling in cancers that are dependent on receptor tyrosine kinases (RTK).
- Selective, potent, and orally active SHP2 allosteric inhibitor
- IC50 of 15.7 nM and Kd of 32 nM
- Higher selectivity for SHP2 over other phosphatases
- Exhibits antitumor activities
- Suppresses MAPK pathway signaling in RTK-dependent cancers
- For research use only
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