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Medchemexpress LLC Iadademstat dihydrochloride | 1431303-72-8 | 99.9% | 50 MG
Supplier: Medchemexpress LLC HY12782T50MG
Iadademstat dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. It shows high selectivity for KDM1A and potent cellular activity in acute myeloid leukemia (AML) cell lines. This inhibitor induces the Cd11b differentiation marker and reduces AML tumor growth, enhancing survival in T-ALL models.
- Inhibits KDM1A by irreversible binding to the FAD cofactor.
- Highly selective for KDM1A over MAO enzymes and KDM1B.
- Potent cellular activity in differentiation and colony formation assays on MLL-translocated AML cell lines.
- Induces Cd11b differentiation marker in MLL-AF9 cells.
- Reduces AML tumor growth in mice and rat xenografts.
- Increases survival time in a disseminated model of T-ALL.
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