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Medchemexpress LLC Iadademstat dihydrochloride | 1431303-72-8 | 99.98% | 303.27 | 10 MG
Supplier: Medchemexpress LLC 10MGHY12782T
Iadademstat dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. It inactivates KDM1A by irreversible binding to the flavin adenine nucleotide (FAD) cofactor. This compound exhibits high selectivity for KDM1A over MAO enzymes and KDM1B, with subnanomolar cellular activity in differentiation and colony formation assays on mixed lineage leukemia (MLL)-translocated acute myeloid leukemia (AML) cell lines.
- Selective irreversible KDM1A inhibitor
- Inactivates KDM1A by binding to FAD cofactor
- High selectivity for KDM1A over MAO enzymes and KDM1B
- Shows subnanomolar cellular activity in MLL-translocated AML cell lines
- Induces Cd11b differentiation marker in MLL-AF9 cells
- Reduces AML tumor growth in mice and rat xenografts
- Increases survival time in a disseminated model of T-ALL
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