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Medchemexpress LLC Ibutilide fumarate | 122647-32-9 | 99.69% | 10 MM 1 ML
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Supplier:  Medchemexpress LLC HYB038710MM/1ML

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Ibutilide fumarate (U70226E) is an action potential-prolonging antiarrhythmic. It is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. It is for research use only.

  • Prolongs cardiac repolarization in vitro and in vivo
  • Potent IKr blocker with an EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells
  • Blocks IKr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone
  • Cells expressing MDR1*7 show marked resistance to Ibutilide

Catalog No. 50-004-06439


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