Medchemexpress LLC Ibutilide (fumarate) | 122647-32-9 | 99.7% | 50 MG

Supplier:  Medchemexpress LLC HYB038750MG

Ibutilide fumarate is an action potential-prolonging antiarrhythmic agent and a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. It is for research use only.

• Potent IKr blocker with an EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells.
• Blocks IKr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone (IC50: 22.5 nM vs 27.4 nM).
• Cells expressing MDR1*7 show resistance (IC50: 105.3 nM vs 27.4 nM).
• Prolongs cardiac repolarization in vitro and in vivo.
• Cumulative doses (0.01, 0.02, and 0.05 mg/kg i.v., 10-min infusion) resulted in polymorphic and monomorphic non-sustained ventricular tachycardia in animal models.
• Increased action potential duration at 90% (APD90) prolongation in congestive heart failure (CHF) dogs compared to controls at 0.01 mg/kg.

Catalog No. 50-004-06107