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Cayman Chemical ICBP112 PosItIve CNTRL 120nmol
Supplier: Cayman Chemical 600853120 NMOL
An activator of the STING pathway induces secretion of IFN-B in human PBMCs (EC50 130 nM) increases serum levels of Ifn-B Il-6 Tnf and Cxcl1 in wild-type but not Sting-/- mice at 2.5 mg/kg inhibits the cytopathic effect of HCoV-229E in infected MRC-5 cells (EC50 3 nM) decreases the level of SARS-CoV-2 RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay decreases tumor volume and increases survival in a CT26 murine colorectal cancer model at 3 mg/kg this compound is expected to exist in one or both tautomeric forms
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