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Medchemexpress LLC Iccb-19 hydrochloride | 1803605-68-6 | 99.3% | 291.84 | 1 ML
Supplier: Medchemexpress LLC HY13877910MM/1ML
ICCB-19 hydrochloride is an inhibitor of TRADD (TNFRSF1A associated via death domain). It binds to the N-terminal domain of TRADD (TRADD-N), which prevents TRADD-N from binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride also acts as an indirect inhibitor of RIPK1 kinase activity and effectively induces autophagy and the degradation of long-lived proteins.
- TRADD (TNFRSF1A associated via death domain) inhibitor.
- Binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2.
- Indirect inhibitor of RIPK1 kinase activity.
- Induces autophagy and degradation of long-lived proteins.
- Inhibits Bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM (In Vitro).
- Reduces inflammatory responses in Tradd-/- mice (In Vivo).
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