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Medchemexpress LLC ICCB-19 (hydrochloride) | 1803605-68-6 | 99.3% | 291.84 | C12H22ClN3OS | 5 MG
Supplier: Medchemexpress LLC HY1387795MG
ICCB-19 hydrochloride is a research-grade small molecule that inhibits TRADD-mediated signaling and indirectly inhibits RIPK1 kinase activity. It has been reported to induce autophagy, modulate TNF-induced inflammatory responses, and affect RIPK1-dependent apoptosis in cellular and animal models.
- Targets TRADD and indirectly inhibits RIPK1 kinase activity.
- Binds TRADD N-terminal domain to disrupt protein interactions.
- Promotes autophagy via K63-linked ubiquitination of Beclin-1.
- Reduces TNF-induced inflammatory gene expression in cell and animal studies.
- Provided as a hydrochloride salt with reported high purity.
- Available as solid and DMSO solution aliquots for research use.
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