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TOPOGEN INC ICE Assay Kit (No AB)
Supplier: TOPOGEN INC TG10200
TopoGEN has developed and published a method for detecting covalent topo/genomic DNA complexes in live cells that is widely utilized in the field. The method, called the ICE Assay (In vivo Complex of Enzyme) originally required a CsCl gradient to purify genomic DNA and specific topo antibodies to detect trapped topo protein in the DNA fraction. This method, while powerful, is slow, labor intense and requires large expensive equipment. We have modified the technique to allow direct isolation of DNA/topo complexes in a single step, omitting the CsCl gradient step and rapidly increasing the throughput of the method. The ICE Assay can be carried out in a day and a half, and the analysis can be conducted on virtually any cell or tissue system as long as proper controls are performed and mono-specific antibody reagents are used. Our new ICE method is rapid and convenient and can be used with any topoisomerase target (I, II, III).
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