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Medchemexpress LLC Icerguastat (Sephin1) | 951441-04-6 | 99.93% | 196.64 | 10 MG
Supplier: Medchemexpress LLC HY111022100MG
Icerguastat (Sephin1) is a Guanabenz derivative that selectively inhibits the phosphatase regulatory subunit PPP1R15A (R15A). It functions by inhibiting eIF2α dephosphorylation, which prolongs the protective cellular response and demonstrates an anti-prion effect.
- Selectively inhibits the phosphatase regulatory subunit PPP1R15A (R15A).
- Inhibits eIF2α dephosphorylation, extending protective cellular responses.
- Demonstrates anti-prion effects in models.
- Prolongs eIF2α phosphorylation in stressed oligodendrocytes.
- Delays the onset of experimental autoimmune encephalomyelitis (EAE) in animal models.
- Prolongs survival in prion-infected mice.
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