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Cayman Chemical icFSP1 trifluoroacetate salt
Supplier: Cayman Chemical 39347500 UG
An inhibitor of FSP1; induces condensation and phase separation of FSP1 in cells at 2.5 µM; does not inhibit FSP1 enzymatic activity in a cell-free assay (IC50 = > 30 µM); induces ferroptosis in HT-1080 fibrosarcoma cells; decreases tumor volume and weight in a B16/F10 murine melanoma model using human FSP1-overexpressing, Gpx4-/-Fsp1-/- B16/F10 cells at 50 mg/kg
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