Medchemexpress LLC Icotinib hydrochloride | 1204313-51-8 | C22H22ClN3O4 | 50 MG

Supplier:  Medchemexpress LLC HY1516450MG

Icotinib Hydrochloride (BPI-2009) is a potent, CNS-penetrant, and specific EGFR inhibitor with an IC50 of 5 nM. It also inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q. This compound functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.

• Potent, CNS-penetrant, and specific EGFR inhibitor
• Inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q
• Has an IC50 of 5 nM for EGFR
• Functions as a click chemistry reagent with an alkyne group
• Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
• Exhibits potent dose-dependent antitumor effects in nude mice
• Blocks EGFR-mediated intracellular tyrosine phosphorylation (IC50=45 nM)
• Well tolerated in mice without significant body weight loss

Catalog No. 50-003-73144