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Apexbio Technology LLC ID-8 147591-46-6 10mg
Supplier: Apexbio Technology LLC B195210
ID-8 (CAS 147591-46-6) is a small-molecule inhibitor targeting dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) enzymes involved in the phosphorylation of tyrosine and serine/threonine residues In human embryonic stem cells (hESCs) ID-8 enhances cell survival and proliferation notably increasing hESC viability and when combined with Wnt3a suppressing Wnt-induced morphological differentiation and downregulating differentiation markers such as GATA6 GSC SOX17 and CDX2 In mouse embryonic stem cells ID-8 sustains self-renewal and pluripotency in serum-free culture supporting expansion and differentiation into derivatives of all three germ layers These properties make ID-8 a valuable tool for research on stem cell maintenance and cell fate regulation
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