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Medchemexpress LLC IDH889 | 1429179-07-6 | 100.0% | 436.48 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY112289100MG

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IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). It shows potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM for IDH1R132H, 0.072 μM for IDH1R132C, and 1.38 μM for IDH1wt. IDH889 also demonstrates potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM.

  • Orally available
  • Brain penetrant
  • Allosteric and mutant specific IDH1 inhibitor
  • Potent selectivity for IDH1 R132* mutations
  • Potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production

Catalog No. 50-004-38374


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