AdipoGen IDO (human) (rec.) (His) (highly active) (50 µg)

Supplier:  AdipoGen AG40B0161C050

Protein. Human IDO (aa 1-403) is fused at the N-terminus to a His-tag. Source: E. coli. Endotoxin content: <0.1EU/µg purified protein (LAL test; Lonza). Liquid. 0.2µm-filtered solution in 10mM Tris, pH 7.5, containing 100mM NaCl and 20% glycerol. Purity: >90% (SDS-PAGE). IDO is a heme enzyme that catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway, causing depletion of tryptophan which can lead to halted growth of microbes as well as T cells. IDO is an immune checkpoint protein, thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation and antioxidant activity. Cancer cells are able to evade the immune system is by hijacking the checkpoint proteins.

Catalog No. 50-205-3254