AdipoGen IDO1 mouse rec His

Supplier:  AdipoGen AG40A0030C050

Protein. Mouse IDO aa 1-407 is fused at the C-terminus to a His-tag. Source E. coli. Endotoxin content <1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in 50mM TRIS-Cl, pH 7.4, containing 1mM EDTA. Purity >90% SDS-PAGE. IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic NOD mice, and as a protective negative regulator in autoimmune disorders.

Catalog No. 50-256-3053