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Genscript Corporation Antibody Protein Proteins Proteins 10 UG 1/EA
Supplier: Genscript Corporation Z0298610
Human Interferon gamma (hIFN-gamma) is amacrophage-activating factor and the lone member of Interferon type II. The active form of IFN-gamma is an antiparallel dimer that interacts with the receptor IFN-gammaR1 and sets off IFN-gamma/JAK/STAT pathway. IFN-gamma signaling does diverse biological functions primarily related to host defense and immune regulation including antiviral and antibacterial defense apoptosis inflammation and innate and acquired immunity. While IFN-gamma–induced inflammatory cascade summons a variety of immune-related cell types such as macrophages natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) IFN-gamma is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers.
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