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Genscript Corporation Antibody Protein Proteins Proteins 1 MG 1/EA
Supplier: Genscript Corporation Z035841
Interferon-gamma (IFN-gamma) also known as Type II interferon or immune interferon is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-beta or the various IFN-Alpha family proteins. Mature IFN-gamma exists as noncovalently-linked homodimers. It shares high sequence indentity with mouse IFN-gamma (86 %). IFN-gamma was originally characterized based on its antiviral activities. The protein also exerts antiproliferative immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-gamma induces the production of cytokines upregulates the expression of class I and II MHC antigens Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions influences isotype switching and potentiates the secretion of immunoglobulins by B cells. Additionally IFN-gamma augments TH1 cell expansion and may be required for TH1 cell differentiation.
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