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Genscript Corporation Antibody Protein Proteins Proteins 1 MG 1/EA
Supplier: Genscript Corporation Z031761
Insulin-like growth factor-binding protein 4 (IGF-BP-4) also known as IBP-4 is a secreted glycoprotein belonging to the IGFBP family. IGF-BP-4 is produced by osteoblasts epidermis ovarian follicles and other tissues. It binds both insulin-like growth factor (IGF) I and II and it circulates in the plasma in both glycosylated and non-glycosylated forms. IGF-BP-4 prolongs the half-life of the IGFs and has been shown to inhibit or stimulate the growth-promoting effects of the IGFs. Pregnancy Associated Plasma Protein A (PAPP-A) proteolytically cleaves IGF-BP-4 and reduces its affinity to bind IGFs and thus serves as an important regulator of IGF-BP-4 function.
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