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AdipoGen IGFL4 human rec His
Supplier: AdipoGen AG40B02513010
Recombinant Protein. Human IGFL4 aa 20-124 is fused at the N-terminus to a His-tag. Endotoxin <0.01EU/µg purified protein LAL test.. Lyophilized. Contains PBS. The Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans IGFL1 to 4 and one in mice mIGFL. mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in the skin or after skin wounding. In humans only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1, 3 and 4 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 formerly TMEM-149. Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.
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