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Medchemexpress LLC IITZ-01 | 1807988-47-1 | 98.18% | 482.51 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY11289710MM/1ML

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IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. For research use only.

  • Potent lysosomotropic autophagy inhibitor.
  • Single-agent antitumor activity.
  • IC50 of 2.62 μM for PI3Kγ.
  • Enhances autophagosomes formation in triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453) by increasing LC3-II levels time- and dose-dependently.
  • Demonstrates potent autophagy inhibitory activity in other breast, lung, and colon cancer cells.
  • Inhibits average breast tumor growth in triple-negative breast tumor models in mice.

Catalog No. 50-004-38759


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